Anogenital warts (AGW) are caused by low-risk HPV types. Current therapies for AGW have notable side effects and high recurrence rates. As DNA viruses such as HPV rely on cellular K+ influx and Ionic contra-viral therapy (ICVT) comprised of digoxin and furosemide inhibits the K+ influx, ICVT might be a potential new treatment for AGW. Recently, a phase 2 randomized-controlled trial showed a reduction in size and viral load of HPV-induced cutaneous warts after 6 weeks of treatment with topical ICVT. This article is protected by copyright. All rights reserved.