No effect of topical digoxin and furosemide gel for patients with external anogenital warts.

Rijsbergen M, Rijneveld R, Todd M, Pagan L, Feiss G, de Koning MNC, van Alewijk DCJG, Klaassen ES, Burggraaf J, Rissmann R, van Poelgeest MIE

Anogenital warts (AGW) are caused by low-risk HPV types. Current therapies for AGW have notable side effects and high recurrence rates. As DNA viruses such as HPV rely on cellular K+ influx and Ionic contra-viral therapy (ICVT) comprised of digoxin and furosemide inhibits the K+ influx, ICVT might be a potential new treatment for AGW. Recently, a phase 2 randomized-controlled trial showed a reduction in size and viral load of HPV-induced cutaneous warts after 6 weeks of treatment with topical ICVT. This article is protected by copyright. All rights reserved.