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Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein.

1 November 2012. doid: 10.1016/j.steroids.2012.08.003

Rad M, Burggraaf J, Sitruk-Ware RL, de Kam ML, Cohen AF, Kluft C

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OBJECTIVE & STUDY DESIGN: In a parallel design, 23 and 22 healthy pre-menopausal women were randomly administered a contraceptive vaginal ring (CVR) delivering 150/15 μg Nestorone®/ethinyl estradiol (EE) daily or an oral contraceptive (OC) containing levonorgestrel and EE (150/30 μg) for three cycles, to compare the effects on C-reactive protein and other markers of inflammation. ANCOVA was performed with baseline values as covariate.

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