Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.

van Amerongen G, Siebenga P, de Kam ML, Hay JL, Groeneveld GJ

A battery of evoked pain tasks (PainCart) was developed to investigate the pharmacodynamic properties of novel analgesics in early-phase clinical research. As part of its clinical validation, compounds with different pharmacological mechanisms of actions are investigated. The aim was to investigate the analgesic effects of classic and nonclassic analgesics compared to a sedating negative control in a randomized placebo-controlled crossover study in 24 healthy volunteers using the PainCart.