Cardiovascular side effects of inhaled salbutamol in hypoxic asthmatic patients.

Burggraaf J, Westendorp RG, in't Veen JC, Schoemaker RC, Sterk PJ, Cohen AF, Blauw GJ

Beta-2 adrenoceptor agonists have been associated with sudden death in asthma patients but the cause and underlying mechanism are unclear. Animal experiments indicate that the combination of hypoxia and beta2 agonists may result in detrimental cardiovascular effects. A study was undertaken to investigate the effect of hypoxia on the systemic vascular effects of salbutamol in patients with asthma who are hypoxic by assessing forearm blood flow (FBF) as a measure of peripheral vasodilatation.