The objective of this paper is to discuss the sequential trial design and its advantages in clinical trials for ALS. The sequential trial design is an alternative to the classical trial design, which permits stopping a study as soon as a treatment effect can be significantly demonstrated or denied.
Sequential designs for clinical trials in amyotrophic lateral sclerosis.
CHDR
Groeneveld GJ, van der Tweel I, Wokke JH, van den Berg LH
