The central effects of benzodiazepines may be attenuated after chronic use by changes in pharmacokinetics, pharmacodynamics or both. This attenuation may be influenced by the dosing pattern and the characteristics of the user population. The objectives of this study were to evaluate drug sensitivity in long-term users of temazepam and lorazepam in a clinical population.
A study of the effects of long-term use on individual sensitivity to temazepam and lorazepam in a clinical population.
CHDR
van Steveninck AL, Wallnöfer AE, Schoemaker RC, Pieters MS, Danhof M, van Gerven JM, Cohen AF
