DNA viruses such as HPV rely on K(+) influx for replication. Both digoxin and furosemide inhibit the K(+) influx by interacting with cell membrane ion co-transporters (Na(+) /K(+) -ATPase and Na(+) -K(+) -2Cl(-) co-transporter-1, respectively). We therefore hypothesized that these two compounds in a topical formulation may be valuable in the treatment of HPV-induced warts. This new approach is called Ionic Contra-Viral Therapy (ICVT).
Topical ionic contra-viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts.
CHDR
van der Kolk T, Dillingh MR, Rijneveld R, Klaassen ES, de Koning MNC, Kouwenhoven STP, Genders RE, Bouwes Bavinck JN, Feiss G, Rissmann R, Burggraaf J
