Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator.

van Griensven JM, Huisman LG, Stuurman T, Dooijewaard G, Kroon R, Schoemaker RC, Kluft K, Cohen AF

To investigate the influence of increased liver blood flow on the pharmacokinetics and pharmacodynamics of recombinant tissue-type plasminogen activator (rt-PA) and to study the changes in endogenous urokinase-type plasminogen activator (u-PA).