Data-Driven Identification of Targets for Fluorescence-Guided Surgery in Non-Small Cell Lung Cancer.

Meijer RPJ, Neijenhuis LKA, Zeilstra AP, Roerink SF, Bhairosingh SS, Hilling DE, Mieog JSD, Kuppen PJK, Sier CFM, Braun J, Burggraaf J, Vahrmeijer AL, Cohen D, Hutteman M

Intraoperative identification of lung tumors can be challenging. Tumor-targeted fluorescence-guided surgery can provide surgeons with a tool for real-time intraoperative tumor detection. This study evaluated cell surface biomarkers, partially selected via data-driven selection software, as potential targets for fluorescence-guided surgery in non-small cell lung cancers: adenocarcinomas (ADC), adenocarcinomas in situ (AIS), and squamous cell carcinomas (SCC).