[Class substitution of medicines--between cost reduction and the position of professionals in health care].

Class substitution (with cost reduction as the purpose) is only possible if there are equivalent drugs in terms of the pharmacological mode of action and safety both at the individual and population level, as well as per indication. Whether two drugs are found to be equivalent, is in part the consequence of the chosen clinically relevant margin in which equivalency can reasonably be assumed and the accuracy with which the outcome measure could be measured. Good data for carrying out class substitution will in many cases be lacking. It is for the health professional to decide which preparation is indicated for a certain patient whereby the pharmacist provides pharmacotherapeutic information and checks the prescribed treatment. The provision of education in medical and pharmaceutical curricula is the most effective manner for limiting drug costs.