Key publication
930
Therapeutic Areas
Methods & challenges

Key publication

Effects of temazepam on saccadic eye movements: concentration-effect relationships in individual volunteers.

Key publication

Pronounced effects of the combination of a new thromboxane antagonist (GR32191) and heparin on bleeding time in man.

Key publication

Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers.

Key publication

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers.

Key publication

Effect of morphological abnormalities on blood retinal barrier permeability in diabetic retinopathy.

Key publication

Long-term effects of tolrestat on symptomatic diabetic sensory polyneuropathy.

Key publication

A multicentre trial of the aldose-reductase inhibitor tolrestat, in patients with symptomatic diabetic peripheral neuropathy. North European Tolrestat Study Group.

Key publication

Intraindividual variability in nifedipine pharmacokinetics and effects in healthy subjects.

Key publication

Serious intercurrent disease in healthy volunteers in clinical pharmacological research.