CHDR has experience with efficiently designed and executed drug development projects in pulmonology and allergology. This includes projects in asthma, COPD, pulmonary fibrosis and allergic rhinitis, but also prophylactic vaccination for common viral respiratory tract infections.


  • Validated clinical exacerbation models of asthma and allergy.
  • Allergen, exercise, cold, dry air and mannitol challenge.
  • Bronchoscopy and biopsies.
  • Sputum induction and analysis (cellular and soluble biomarkers).
  • Exhaled nitric oxide measurements (including peripheral fractions).
  • Exhaled breath condensate collection and analysis.
  • Spirometry, body box, IOS.
  • Nasal nitric oxide measurements.
  • Nasal lavage, brushings, biopsies & scrapings.
  • (Diluted) skin prick test.
  • Validation of novel sampling methods and biomarkers.
  • Validation of novel detection techniques (e.g. in sputum, blood, exhaled air).
  • A large variety of biomarkers in blood, urine, sputum, exhaled breath, nasal lavage/brush.
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