Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation.

Schrier L, Zuiker R, Merkus FW, Klaassen ES, Guan Z, Tuk B, van Gerven JM, van der Geest R, Groeneveld GJ

To evaluate the pharmacokinetics, pharmacodynamics, nasal tolerance and effects on sedation of a highly concentrated aqueous intranasal midazolam formulation (Nazolam) and to compare these to intravenous midazolam.