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A novel maturation function for clearance of the cytochrome P450 3A substrate midazolam from preterm neonates to adults.
1 July 2013. doid: 10.1007/s40262-013-0050-0
Ince I, de Wildt SN, Wang C, Wang C, Peeters MY, Burggraaf J, Jacqz-Aigrain E, van den Anker JN, Tibboel D, Danhof M, Knibbe CA
View publicationMajor changes in cytochrome P450 (CYP) 3A activity may be expected in the first few months of life with, later, relatively limited changes. In this analysis we studied the maturation of in vivo CYP3A-mediated clearance of midazolam, as model drug, from preterm neonates of 26Â weeks gestational age (GA) to adults.
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